Kiyoung Lee
Kiyoung Lee
전공analytical chemistry Contact
연락처
031-850-9446
kyleejh@cha.ac.kr
학력
- B.S., College of Pharmacy, Sungkyunkwan University
- Ph.D., College of Pharmacy, Seoul National University
- Structural analysis of disease-causing proteins and drugs using NMR, crystallography, and other biophysical techniques.
- Nanodisc-based analytical platforms for studying pathologically important interactions of membrane proteins (e.g., oncogenic proteins) and for elucidating action mechanism of drugs targeting these membrane proteins.
- Application of ligand-observed NMR techniques to discover and analyze drug candidates that inhibit cellular target proteins.
[전문분야]
경력
- 2013-2015 : Research Institute of Pharmaceutical Sciences,
- College of Pharmacy, Seoul National University (서울대학교 종합약학연구소 연구원)
- 2016-2021 : University of Toronto / University Health Network, Canada (토론토대학교병원 연구원)
논문
- Ki-Young Lee, Masahiro Enomoto, Teklab Gebregiworgis, Geneviève MC Gasmi-Seabrook, Mitsuhiko Ikura, Christopher B Marshall “Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization” Chem Sci. 2021 Sep 7;12(38):12827-12837.
- Christopher B Marshall, Fenneke KleinJan, Teklab Gebregiworgis, Ki-Young Lee, Zhenhao Fang, Ben J Eves, Ningdi F Liu, Geneviève M C Gasmi-Seabrook, Masahiro Enomoto, Mitsuhiko Ikura “NMR in integrated biophysical drug discovery for RAS: past, present, and future” J Biomol NMR. 2020 Nov;74(10-11):531-554.
- Kyu-Yeon Lee, Dong-Gyun Kim, Ki-Young Lee, Chinar Pathak, Ji Sung Koo, Hee-Chul Ahn, Bong-Jin Lee “Structural and functional study of SaAcP, an acylphosphatase from Staphylococcus aureus” Biochem Biophys Res Commun. 2020 Nov 5;532(2):173-178.
- Hyun-Jong Eun, Ki-Young Lee, Dong-Gyun Kim, Daseul Im, Bong-Jin Lee “Crystal structure of the YoeB Sa1-YefM Sa1 complex from Staphylococcus aureus” Biochem Biophys Res Commun. 2020 Jun 18;527(1):264-269.
- Zhenhao Fang, Ki-Young Lee, Ku-Geng Huo, Geneviève Gasmi-Seabrook, Le Zheng, Nadeem Moghal, Ming-Sound Tsao, Mitsuhiko Ikura, Christopher B Marshall “Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane” Proc Natl Acad Sci. 2020 Jun 2;117(22):12101-12108.
- Ki-Young Lee, Zhenhao Fang, Masahiro Enomoto, Genevieve Gasmi-Seabrook, Le Zheng, Shohei Koide, Mitsuhiko Ikura, Christopher B. Marshall “Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement” Angew Chem Int Ed Engl. 2020 Jun 26;59(27):11037-11045.
- Benjamin M M Grant, Masahiro Enomoto, Sung-In Back, Ki-Young Lee, Teklab Gebregiworgis, Noboru Ishiyama, Mitsuhiko Ikura, Christopher B Marshall “Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety” Sci Signal. 2020 Mar 31;13(625):eaaz0344.
- DongWon Park, Hye-Jin Yoon, Ki-Young Lee, Sung-Jean Park, Seung-Ho Cheon, Hyung Ho Lee, Sang Jae Lee, Bong-Jin Lee “Crystal structure of proteolyzed VapBC and DNA-bound VapBC from Salmonella enterica Typhimurium LT2 and VapC as a putative Ca 2+ -dependent ribonuclease” FASEB J. 2020 Feb;34(2):3051-3068.
- Joon Sung Park, Min Chul Park, Ki-Young Lee, Peter C. Goughnour, Seung Jae Jeong, Hyoun Sook Kim, Hyun-Jung Kim, Bong-Jin Lee, Sunghoon Kim, ByungWoo Han “Unique N-terminal extension domain of human asparaginyl-tRNA synthetase elicits CCR3-mediated chemokine activity” Int J Biol Macromol. 2018 Dec;120(Pt A):835-845.