B.S., College of Pharmacy, Sungkyunkwan University
Ph.D., College of Pharmacy, Seoul National University
[전문분야]
Utilization of lipid nanodisc (i.e., nanoparticle)-based systems for (i) drug formulation and delivery and (ii) studying pathologically important interactions of membrane proteins (e.g., oncogenic RAS) and interactions between drug and these membrane proteins.
Pharmaceutical NMR and other analytical tools for (i) studying physicochemical properties of drugs, (ii) evaluating drug formulations, and (iii) discovering new drug candidates.“
경력
2013-2015 : Research Institute of Pharmaceutical Sciences,
College of Pharmacy, Seoul National University (서울대학교 종합약학연구소 연구원)
2016-2021 : University of Toronto / University Health Network, Canada (토론토대학교병원 연구원)
논문
최근 논문(2020년 이후)
Ki-Young Lee, Mitsuhiko Ikura, Christopher B Marshall, “The Self-Association of the KRAS4b Protein is Altered by Lipid-Bilayer Composition and Electrostatics” Angew Chem Int Ed Engl. 2023 Apr 24;62(18) (대표논문, IF= ~17)
Ki-Young Lee and Bong-Jin Lee “Dynamics-Based Regulatory Switches of Type II Antitoxins: Insights into New Antimicrobial Discovery” Antibiotics (Basel) 2023 Mar 23;12(4):637
Ki-Young Lee, Masahiro Enomoto, Teklab Gebregiworgis, Geneviève MC Gasmi-Seabrook, Mitsuhiko Ikura, Christopher B Marshall “Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization” Chem Sci. 2021 Sep 7;12(38):12827-12837. (대표논문, IF= ~10)
Christopher B Marshall, Fenneke KleinJan, Teklab Gebregiworgis, Ki-Young Lee, Zhenhao Fang, Ben J Eves, Ningdi F Liu, Geneviève M C Gasmi-Seabrook, Masahiro Enomoto, Mitsuhiko Ikura “NMR in integrated biophysical drug discovery for RAS: past, present, and future” J Biomol NMR. 2020 Nov;74(10-11):531-554.
Kyu-Yeon Lee, Dong-Gyun Kim, Ki-Young Lee, Chinar Pathak, Ji Sung Koo, Hee-Chul Ahn, Bong-Jin Lee “Structural and functional study of SaAcP, an acylphosphatase from Staphylococcus aureus” Biochem Biophys Res Commun. 2020 Nov 5;532(2):173-178.
Hyun-Jong Eun, Ki-Young Lee, Dong-Gyun Kim, Daseul Im, Bong-Jin Lee “Crystal structure of the YoeB Sa1-YefM Sa1 complex from Staphylococcus aureus” Biochem Biophys Res Commun. 2020 Jun 18;527(1):264-269.
Zhenhao Fang, Ki-Young Lee, Ku-Geng Huo, Geneviève Gasmi-Seabrook, Le Zheng, Nadeem Moghal, Ming-Sound Tsao, Mitsuhiko Ikura, Christopher B Marshall “Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane” Proc Natl Acad Sci. 2020 Jun 2;117(22):12101-12108. (대표논문, IF= ~13)
Ki-Young Lee, Zhenhao Fang, Masahiro Enomoto, Genevieve Gasmi-Seabrook, Le Zheng, Shohei Koide, Mitsuhiko Ikura, Christopher B. Marshall “Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement” Angew Chem Int Ed Engl. 2020 Jun 26;59(27):11037-11045. (대표논문, IF= ~17)
Benjamin M M Grant, Masahiro Enomoto, Sung-In Back, Ki-Young Lee, Teklab Gebregiworgis, Noboru Ishiyama, Mitsuhiko Ikura, Christopher B Marshall “Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety” Sci Signal. 2020 Mar 31;13(625):eaaz0344.
DongWon Park, Hye-Jin Yoon, Ki-Young Lee, Sung-Jean Park, Seung-Ho Cheon, Hyung Ho Lee, Sang Jae Lee, Bong-Jin Lee “Crystal structure of proteolyzed VapBC and DNA-bound VapBC from Salmonella enterica Typhimurium LT2 and VapC as a putative Ca 2+ -dependent ribonuclease” FASEB J. 2020 Feb;34(2):3051-3068.