김은희
김은희 학과장
전공예방약학, 독성학
연락처
031-881-7179
ehkim@cha.ac.kr
학력
- 서울대학교 농생물학과, 학사
- 서울대학교 대학원 농생명공학부, 석사
- 서울대학교 대학원 약학과, 박사(약품생화학전공)
- 한국인 호발 소화기질환 기전, 치료 및 예방전략 발굴 연구
- 헬리코박터균 감염 유발 위질환 치료 및 예방 연구
- 대사성 질환 관련 신약개발후보물질의 전임상 평가 및 기전 연구
- 염증성 질환과 암성 질환과의 연관 규명을 기초로 염증제어를 통한 암예방 연구
[전문분야]
경력
- Dartmouth College, Medical School, 박사후연구원
- 가천대학교 이길여암당뇨연구원, 연구 조교수
- (현)CHA의과학대학교 약학대학, 조교수
- (현)대한암예방학회지 편집위원
- (현)대한약학회 정회원 (약품생화학 및 분자생물학 분과)
논문
- [주요연구내용]
- 한국인 호발 소화기질환 기전, 치료 및 예방전략 발굴 연구
- 헬리코박터균 감염 유발 위질환 치료 및 예방 연구
- 대사성 질환 관련 신약개발후보물질의 전임상 평가 및 기전 연구
- 염증성 질환과 암성 질환과의 연관 규명을 기초로 염증제어를 통한 암예방 연구
- Song MY, Lee DY, Park SY, Seo SA, Hwang JS, Heo SH, Kim EH (2021) Steamed ginger extract exerts anti-inflammatory effects in Helicobacter pylori-infected gastric epithelial cells through inhibition of NF-kB. Journal of Cancer Prevention, 26(4):289-297.
- Kim TW, Kwon H, Lee DY, Kim DJ, Jeon Y, Shin H, Kim HS, Hur J, Lim C, Kim EH, Shin D, Kim SH (2021) Concise syntheses and anti-inflammatory effects of isocorniculatolide B and corniculatolide B and C. Bioorganic Chemistry, 116: 105398.
- Lee DY, Song MY and Kim EH (2021) Trefoil factor 1 suppresses epithelial-mesenchymal transition through inhibition of transforming growth factor-beta signaling in gastric cancer cells. Journal of Cancer Prevention, 26(2): 137-144.
- Lee DY, Song MY and Kim EH (2021) Role of oxidative stress and Nrf2/KEAP1 signaling in colorectal cancer: Mechanisms and therapeutic perspectives with phytochemicals. Antioxidants, 10(5), 743-765.
- Song MY, Lee DY, Chun KS and Kim EH (2021) The role of NRF2/KEAP1 signaling pathway in cancer metabolism. International Journal of Molecular Sciences, 22(9), 4376-4391.
- Park JY, Saeidi S, Kim EH, Kim DH, Na HK, Keum JS, Surh YJ (2021) Heregulin-β1 activates NF-E2-related factor 2 and induces manganese superoxide dismutase expression in human breast cancer cells via protein kinase B and extracellular signal-related protein kinase signaling pathways. Journal of Cancer Prevention, 26(1):54-63.
- Kim EH*, Kim SJ, Na HK, Han W, Kim NJ, Suh YG, and Surh YJ* (2021) 15-Deoxy-Δ12, 14-prostaglandin J2 upregulates VEGF expression via NRF2 and heme oxygenase-1 in human breast cancer cells, Cells, 10(3), 526-549.Hyun Su Kim, Sungkyun Chung, Moon-Young Song, Changjin Lim, Hyeyoung Shin, Joonseong Hur, Hyuk Kwon, Young-Ger Suh, Eun-Hee Kim*, Dongyun Shin* and Seok-Ho Kim* (2020) Efficient and divergent enantioselelctive syntheses of DHPVs and anti-inflammatory effect on IEC-6 cells. Molecules, 25(9):2215-2223.
- Moon-Young Song, Da-Young Lee, Eun-Hee Kim (2020) Anti-inflammatory and anti-oxidative effect of Korean propolis on Helicobacter pylori-induced gastric damage in vitro, Journal of Microbiology, 58(10): 878-885.
- Lee DY, Yun SM, Song MY, Jung K and Kim EH (2020) Cyanidin chloride induces apoptosis by inhibiting NF-kB signaling through activation of Nrf2 in colorectal cancer cells. Antioxidants, 9(4): 285-303.
- Lee DY, Hong KS, Song MY, Yun SM, Ji SD, Son JG and Kim EH (2020) Hepatoprotective effects of steamed and freeze-dried mature silkworm larval powder against ethanol-induced fatty liver disease in rats. Foods, 9(3), 285-296.
- Lee DY, Yun SM, Song MY, Ji SD, Son JG and Kim EH (2020) Administration of steamed and freeze-dried mature silkworm larval powder prevents hepatic fibrosis and hepatocellular carcinogenesis by blocking TGF-β/STAT3 signaling cascades in rats. Cells, 9(3), 568-583.
- Lee DY and Kim EH (2019) Therapeutic effects of amino acids in liver diseases: Current studies and future perspectives, Journal of Cancer Prevention, 24(2):72-78.
- Yun SM, Kim SH and Kim EH (2019) The molecular mechanism of TGF-β signaling for intestinal fibrosis: A Mini-review, Frontiers in Pharmacology, 10: 162.
- Suh J, Kim DH, Kim EH, Park SA, Park JM, Jang JH, Kim SJ, Na HK, Kim ND, Kim NJ, Suh YG, Surh YJ (2018) 15-Deoxy-Δ12,14-prostaglandin J2 activates PI3K-Akt signaling in human breast cancer cells through covalent modification of the tumor suppressor PTEN at cysteine 136, Cancer Letters, 424: 30-45.
- Hong KS, Yun SM, Cho JM, Lee DY, Ji SD, Son JD and Kim EH* (2018) Silkworm (Bombyx mori) powder supplementation alleviates alcoholic fatty liver disease in rats. Journal of Functional Foods, 43: 29-36.
- Cho JM, Yun SM, Choi YH, Heo J, Kim NJ, Kim SH and Kim EH* (2018) Xanthohumol prevents dextran sulfate sodium-induced colitis via inhibition of IKKβ/NF-κB signaling in mice, Oncotarget, 9: 866-880.
[논문] (최근 5년간. *교신저자 논문)
저서/역서/편서
- 핵심독성학, (주)바이오사이언스, 2018
- 예방약학, 신일북스, 2017
- 약품생화학∙분자생물학 총정리, 신일북스, 2015
- 견사단백질을 갖는 누에를 함유하는 비알코올성 간염의 예방 또는 치료용 조성물. 등록번호: 10-1856448, 등록일: 2018.05.03
- 견사단백질을 갖는 누에를 함유하는 위염 또는 소화성 궤양의 예방 또는 치료용 조성물. 등록번호: 10-1794660, 등록일: 2017.11.01
- 견사단백질을 갖는 누에를 함유하는 알코올성 간염의 예방 또는 치료용 조성물. 등록번호: 10-1793537, 등록일: 2017.10.30
- 에스-알릴-엘-시스테인을 유효성분으로 포함하는 대장염 예방 또는 치료용 조성물 및 이를 포함하는 의약제제. 등록번호: 10-1320945, 등록일: 2013.10.16
[특허]