서영거

서영거 교수

전공약품제조화학

연락처 031-850-9006 ygsuh@cha.ac.kr

학력

1975 서울대학교 약학대학 학사
1980 서울대학교 대학원 유기약품제조 석사
1987 University of Pittsburgh, 유기화학 박사

경력

1988–2016 서울대학교 약학대학 조교수, 부교수, 교수
2003-2004 대한약학회 편집위원장
2006-2010 기술융합신약개발사업단 총괄책임자
2006–2009, 2015-2017 보건정책심의위원
2007-2009 한국약학대학 협의회 회장
2007-2011 서울대학교 약학대학 학장
2010–2013 식약처 연구정책 및 연구윤리심의위원장 및 위원
2011–2014 글로벌 혈관질환 신약후보물질 개발사업단 총괄책임자
2011–2014 한국약학교육평가원 원장
2012- Asian Journal of Organic Chemistry Member of Editorial Board
2013- Asian Federation for Medicinal Chemistry Fellow
2013–2014 대한약학회 회장
2014-현재 한국과학기술한림원 정회원
2014–2016 한국과학기술단체총연합회 부회장
2015 한국유기합성학회 회장
2011–2016 서울대학교 평의원회 교육위원장
2015 AIMECS 공동조직위원장
2016 영국왕립화학회(Royal Society of Chemistry) Fellow
2016–2021 차의과학대학교 약학대학 학장
2021– 차의과학대학교 교학부총장

논문

Taewoo Kim,† Haejun Oh,† Hyo-In Kim,† Yoonsu Jeon, Hyeyoung Shin, Hyun Su Kim, Juhee Lim, Changjin Lim, Jakyung Yoo, Young-Ger Suh, Woo Sung Son, Hyun jin Choi,* and Seok-Ho Kim* Discovery of New ERRγ Agonists and Dopaminergic Neuronal Phenotype Enhancement of SH-SY5Y cells Bioorganic Chemistry 2022, 122, 105716.
Song K, Rajasekaran N, Chelakkot C, Lee HS, Paek SM, Yang H, Jia L, Park HG, Son WS, Kim YJ, Choi JS, Jeong HM, Suh YG, Yun H, Shin YK. Macrosphelide A Exhibits a Specific Anti-Cancer Effect by Simultaneously Inactivating ENO1, ALDOA, and FH. Pharmaceuticals 2021, 14 (10),1060.
Cho JH, Park S, Kim S, Kang SM, Woo TG, Yoon MH, Lee H, Jeong M, Park YH, Kim H, Han YT, Suh YG, Kim BH, Kwon Y, Yun H, Park BJ. RKIP Induction Promotes Tumor Differentiation via SOX2 Degradation in NF2-Deficient Conditions. Cancer Res. 2021, ASAP
Kim DG, Huddar S, Lim S, Kong J, Lee Y, Park CM, Lee S, Suh YG, Kim M, Lee K, Lee S, Kim S. Allosteric Inhibition of the Tumor-Promoting Interaction Between Exon 2-Depleted Splice Variant of Aminoacyl-Transfer RNA Synthetase-Interacting Multifunctional Protein 2 and Heat Shock Protein 70. J Pharmacol Exp Ther. 2021, 379(3):358-371.
Kiyonga AN, Park GH, Kim HS, Suh YG, Kim TK, Jung K. An Efficient Ionic Liquid-Mediated Extraction and Enrichment of Isoimperatorin from Ostericum koreanum (Max.) Kitagawa. Molecules. 2021, 29;26(21):6555.
Kim AR, Lee S, Shin JU, Seok SH, Suh YG, Kim DH. A Michael Acceptor Analogue, SKSI-0412, Down-Regulates Inflammation and Proliferation Factors through Suppressing Signal Transducer and Activator of Transcription 3 Signaling in IL-17A-Induced Human Keratinocyte. Int J Mol Sci. 22(16):8813
Jo DH, Lee S, Bak E, Cho CS, Han YT, Kim K, Suh YG, Kim JH. Anti-tumor Activity of Novel STAT3 Inhibitors on Retinoblastoma. Mol Pharmacol. 2021, 100(1):63-72
Kim SH, Yum HW, Kim SH, Kim SJ, Kim K, Kim C, Suh YG, Surh YJ. Topically Applied Taurine Chloramine Protects against UVB-Induced Oxidative Stress and Inflammation in Mouse Skin. Antioxidants. 2021, 10(6):867
Lee S, Kwon NH, Seo B, Lee JY, Cho HY, Kim K, Kim HS, Jung K, Jeon YH, Kim S, Suh YG. Discovery of novel potent migrastatic Thiazolo[5,4-b]pyridines targeting Lysyl-tRNA synthetase (KRS) for treatment of Cancer metastasis. Eur J Med Chem. 2021, 218:113405.
Kim SH, Yum HW, Kim SH, Kim W, Kim SJ, Kim C, Kim K, Suh YG, Surh YJ. Protective Effects of Taurine Chloramine on Experimentally Induced Colitis: NFκB, STAT3, and Nrf2 as Potential Targets. Antioxidants. 2021, 10(3):479.
Kim EH, Kim SJ, Na HK, Han W, Kim NJ, Suh YG, Surh YJ. 15-Deoxy-Δ12,14-prostaglandin J2 Upregulates VEGF Expression via NRF2 and Heme Oxygenase-1 in Human Breast Cancer Cells. Cells. 2021, 10(3):526.
Kim SJ, Cho NC, Han B, Kim K, Hahn YI, Kim KP, Suh YG, Choi BY, Na HK, Surh YJ. 15-Deoxy-Δ12,14 -prostaglandin J2 binds and inactivates STAT3 via covalent modification of cysteine 259 in H-Ras-transformed human breast epithelial cells. FEBS Lett. 202, 595(5):604-622.
Kiyonga AN, Hong G, Kim HS, Suh YG, Jung K. Facile and Rapid Isolation of Oxypeucedanin Hydrate and Byakangelicin from Angelica dahurica by Using [Bmim]Tf2N Ionic Liquid. Molecules. 2021, 26(4):830.
Kim HI, Lee S, Lim J, Chung S, Koo TS, Ji YG, Suh YG, Son WS, Kim SH, Choi HJ. ERRγ ligand HPB2 upregulates BDNF-TrkB and enhances dopaminergic neuronal phenotype. Pharmacol Res. 2021, 165:105423.
Kim HS, Park H, Lim J, Lim C, Kim T, Lee S, Hur J, Sim J, Choi HJ, Suh YG, Collective Syntheses of Guaiane Sesquiterpenes: Stereoselective Syntheses of (+)-Dysodensiol F, (+)-10β,14-Dihydroxy-allo-aromadendrane, and (-)-Dendroside C Aglycon, J Org Chem, 2020, 85(21):13779-13792
Hong SJ, Kim JT, Kim SJ, Cho NC, Kim K, Lee S, Suh YG, Cho KC, Kim KP, Surh YJ, An Electrophilic Deguelin Analogue Inhibits STAT3 Signaling in H-Ras-Transformed Human Mammary Epithelial Cells: The Cysteine 259 Residue as a Potential Target, Biomedicines, 2020, 8(10):407
Park SK, Byun WS, Lee S, Han YT, Jeong YS, Jang K, Chung SJ, Lee J, Suh YG, Lee SK, A novel small molecule STAT3 inhibitor SLSI-1216 suppresses proliferation and tumor growth of triple-negative breast cancer cells through apoptotic induction, Biochem Pharmacol, 2020, 178:114053.
Kim HS, Chung S, Song MY, Lim C, Shin H, Hur J, Kwon H, Suh YG, Kim EH, Shin D, Kim SH, Efficient and Divergent Enantioselective Syntheses of DHPVs and Anti-Inflammatory Effect on IEC-6 Cells, Molecules, 2020, 25(9):2215
Hur J, Kim AR, Kim HS, Lim C, Kim T, Kim TA, Sim J, Suh YG, Concise Synthesis of Catechin Metabolites 5-(3′,4′-Dihydroxyphenyl)-γ-valerolactones (DHPV) in Optically Pure Form and Their Stereochemical Effects on Skin Wrinkle-Reducing Activities, Molecules, 2020, 25(8):1970
Sivaraman A, Kim DG, Bhattarai D, Kim M, Lee HY, Lim S, Kong J, Goo JI, Shim S, Lee S, Suh YG, Choi Y, Kim S, Lee K, Synthesis and Structure-Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy, J Med Chem, 2020, 63(10):5139-5158
Lee S, Kim DG, Kim K, Kim T, Lim S, Kong H, Kim S, Suh YG, 2-Aminophenylpyrimidines as Novel Inhibitors of Aminoacyl-tRNA Synthetase Interacting Multifunctional Protein 2 (AIMP2)-DX2 for Lung Cancer Treatment, J Med Chem, 2020, 63(8):3908-3914
More KN, Lee YJ, Kim KJ, Suh YG, Son YJ, Chang DJ, Effect of TRPV1 Antagonist SC0030, a Potent Painkiller, on RANKL-mediated Osteoclast Differentiation Involved in Bone Resorption, Bull. Korean Chem. Soc, 2020, 41:488-491
Jeong YS, Baek M, Lee S, Kim MS, Maeng HJ, Lee JH, Suh YG, Chung SJ, Development and Validation of Analytical Method for SH-1242 in the Rat and Mouse Plasma by Liquid Chromatography/Tandem Mass Spectrometry, Molecules, 2020, 25(3):531
Jeong M, Lee H, Kim G, Jo J, Chang JW, Jung JH, Suh YG, Yun H, Divergent Synthetic Route to Oxidized Benzofulvene Sesquiterpenoids: Protecting-Group-Free Total Synthesis of Nicotianasesterpenes A, B, and a Polygonum Sesquiterpenoid, Eur. J. Org. Chem, 2019, 39:6714–6719
Lim C, Park JG, Kang KB, Suh YG, Identification and Semi-Synthesis of 3-O-Protocatechuoylceanothic Acid, a Novel and Natural GPR120 Agonist, Molecules, 2019, 24(19):3487
Jo J, Jeong M, Ahn JS, Akter J, Kim HS, Suh YG, Yun H, Total Synthesis of Anmindenol A and Its Application to the Design, Synthesis, and Biological Evaluation of Derivatives Thereof, J Org Chem, 2019, 84(17):10953-10961
Kiyonga AN, An JH, Lee KY, Lim C, Suh YG, Chin YW, Jung K, Rapid and Efficient Separation of Decursin and Decursinol Angelate from Angelica gigas Nakai using Ionic Liquid, (BMIm)BF4, Combined with Crystallization, Molecules, 2019, 24(13):2390
Go YH, Lim C, Jeong HC, Kwon OS, Chung S, Lee H, Kim W, Suh YG, Son WS, Lee MO, Cha HJ, Kim SH, Structure-Activity Relationship Analysis of YM155 for Inducing Selective Cell Death of Human Pluripotent Stem Cells, Front Chem, 2019, 7:298
Ko H, Lee JH, Kim HS, Kim T, Han YT, Suh YG, Chun J, Kim YS, Ahn KS, Novel Galiellalactone Analogues Can Target STAT3 Phosphorylation and Cause Apoptosis in Triple-Negative Breast Cancer, Biomolecules, 2019, 9(5):170
Lee EJ, Kim SJ, Hahn YI, Yoon HJ, Han B, Kim K, Lee S, Kim KP, Suh YG, Na HK, Surh YJ, 15-Keto prostaglandin E2 suppresses STAT3 signaling and inhibits breast cancer cell growth and progression, Redox Biol, 2019, 23:101175
Kim HS, Hoang VH, Hong M, Chul Kim K, Ann J, Nguyen CT, Seo JH, Choi H, Yong Kim J, Kim KW, Sub Byun W, Lee S, Lee S, Suh YG, Chen J, Park HJ, Cho TM, Kim JY, Seo JH, Lee J, Investigation of B,C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors for use as anti-breast cancer agents, Bioorg Med Chem, 2019, 27(7):1370-1381
Sim J, Kim SH, Hur J, Lim C, Kim HS, Suh YG, Indium(III) Triflate Catalyzed Glycosylation via an Ambient Activation of Glycosyl Fluoride, Asian Journal of Organic Chemistry, 2019, 8:107-110.
Kim M, Jang J, Choi G, Chung S, Lim C, Hur J, Kim HS, Na Y, Son WS, Suh YG, Jung JW, Kim SH, Conversion of Medium-Sized Lactams to α-Vinyl or α-Acetylenyl Azacycles via N,O-Acetal TMS Ethers, Molecules. 2018, 23(11). pii: E3023.
An JH, Youn W, Kiyonga AN, Lim C, Park M, Suh YG, Ryu HC, Kim JS, Park CW, Jung K, Kinetics of the Solution-Mediated Polymorphic Transformation of the Novel L-Carnitine Orotate Polymorph, Form-II, Pharmaceutics. 2018, 10(4). pii: E171.
An H, Lee S, Lee JM, Jo DH, Kim J, Jeong YS, Heo MJ, Cho CS, Choi H, Seo JH, Hwang S, Lim J, Kim T, Jun HO, Sim J, Lim C, Hur J, Ahn J, Kim HS, Seo SY, Na Y, Kim SH, Lee J, Lee J, Chung SJ, Kim YM, Kim KW, Kim SG, Kim JH, Suh YG*, Novel Hypoxia-Inducible Factor 1α (HIF-1α) Inhibitors for Angiogenesis-Related Ocular Diseases: Discovery of a Novel Scaffold via Ring-Truncation Strategy, Journal of Medicinal Chemistry, 2018, 61(20):9266-9286.
Moon H, Yoon H, Lim C, Jang J, Yi JJ, Lee JK, Lee J, Na Y, Son WS, Kim SH* and Suh YG*, Asymmetric Synthesis of (−)-6-Desmethyl-Fluvirucinine A1 via Conformationally-Controlled Diastereoselective Lactam-Ring Expansions, Molecules 2018, 23(9), 2351.
An JH, Lim C, Kiyonga AN, Chung IH, Lee IK, Mo K, Park M, Youn W, Choi WR, Suh YG, Jung K, Co-Amorphous Screening for the Solubility Enhancement of Poorly Water-Soluble Mirabegron and Investigation of Their Intermolecular Interactions and Dissolution Behaviors, Pharmaceutics, 2018, 10(3). pii: E149.
Munhyung Bae, Jedo Oh, Eun Seo Bae, Joonseok Oh, Joonseong Hur, Young-Ger Suh, Sang Kook Lee, Jongheon Shin, Dong-Chan Oh* “WS9326H, an Antiangiogenic Pyrazolone-Bearing Peptide from an Intertidal Mudflat Actinomycete” Org. Lett. 2018, 20, 1999-2002
Jinyoung Suh, Do-Hee Kim, Eun-Hee Kim, Sin-Aye Park, Jong-Min Park, Jeong-Hoon Jang, Su-Jung Kim, Hye-Kyung Na, Nam-Doo Kim, Nam-Jung Kim, Young Ger Suh, Young-Joon Surh* “15-Deoxy-D12,14-prostaglandin J2 activates PI3K-Akt signaling inhuman breast cancer cells through covalent modiﬁcation of the tumorsuppressor PTEN at cysteine 136” Cancer Lett. 2018, 424, 30-45
Jaebong Jang, Sooyoung Chung, Youjeong Choi, Hye Young Lim, Yeongeon Son, Sung Kook Chun, Gi Hoon Sone, Kyungjin Kim, Young-Ger Suh⁎, Jong-Wha Jung* “The cryptochrome inhibitor KS15 enhances E-box-mediated transcription by disrupting the feedback action of a circadian transcription-repressor complex” Life Sci. 2018, 200, 49-55
Wonki Kim, Seung Hyeon Kim, Jeong-Hoon Jang, Chaekyun Kim, Kyeojin Kim, Young-Ger Suh, Yeonsoo Joe, Hun Taeg Chung, Young-Nam Cha, Young-Joon Surh* “Role of heme oxygenase-1 in potentiation of phagocytic activity ofmacrophages by taurine chloramine: Implications for the resolution ofzymosan A-induced murine peritonitis” Cell. Immunol. 2018, 327, 36-46
Joonseong Hur, Jaebong Jang, Jaehoon Sim, Woo Sung Son, Hee-Chul Ahn, Tae Sung Kim, Yern-Hyerk Shin, Changjin Lim, Seungbeom Lee, Hongchan An, Seok-Ho Kim, Dong-Chan Oh, Eun-Kyeong Jo, Jichan Jang, Jeeyeon Lee, and Young-Ger Suh* “Conformation-Enabled Total Syntheses of Ohmyungsamycins A and B and Structural Revision of Ohmyungsamycin B” Angew. Chem. Int. Ed. 2018, 57, 3069-3073
Hyun Su Kim, Taewoo Kim, Jungmin Ahn, Hwayoung Yun, Changjin Lim, Jaebong Jang, Jaehoon Sim, Hongchan An, Young-Joon Surh, Jeeyeon Lee, Young-Ger Suh* “Asymmetric Total Synthesis of (+)-(3E)-Pinnatifidenyne via Abnormally Regioselective Pd(0)-Catalyzed Endocyclization” J. Org. Chem. 2018, 83, 1997-2005.
Jaehoon Sim, Hyunkyung Park, Juhee Lim, Inah Yoon, Changjin Lim, Hongchan An, Hwayoung Yun, Hyun Jin Choi, and Young-Ger Suh* “Stereoselective Synthesis of 1,4,5-Tri-cis-guaiane Sesquiterpene: First Total Synthesis of (-)-Dendroside C Aglycon.” Org. Lett. 2018, 20, 586-589
Seung Hyeon Kim, Xiancai Zhong, Wonki Kim, Kyeojin Kim, Young-Ger Suh, Chaekyun Kim, Yeonsoo Joe, Hun Taeg Chung, Young-Nam Cha, and Young-Joon Surh* “Taurine chloramine potentiates phagocytic activity of peritoneal macrophages through up-regulation of dectin-1 mediated by heme oxygenase-1-derived carbon monoxide” FASEB J. 2018, 32, 2246-2256
Changjin Lim, Jungmin Ahn, Jaehoon Sim, Hwayoung Yun, Joonseong Hur, Hongchan An, Jaebong Jang, Seungbeom Lee, and Young-Ger Suh* “Total synthesis of (+)-brasilenyne via concise construction of an oxonane framework containing a 1,3-cis,cis-diene” Chem. Commun. 2018, 54, 467-470

저서/역서/편서

[특허]

DHPV의 신규한 합성방법, 10-2003033, 2019-07-17, KR
신규한 락톤 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 STAT3 관련 질환의 예방 또는 치료용 약학적 조성물, 10-1830262, 2018-02-12, KR