이기영
이기영 교수
전공물리화학, 분석화학
연락처
031-850-9446
kyleejh@cha.ac.kr
학력
- B.S., College of Pharmacy, Sungkyunkwan University
- Ph.D., College of Pharmacy, Seoul National University
- Utilization of nanodisc-based systems for biophysical studies of disease-related proteins and those in complex with drugs
- Lipid nanoparticle-based formulations of protein/peptide drugs using NMR spectroscopy and other physicochemical methods
- Development of new analytical platforms for discovering new drug candidates
[전문분야]
경력
- 2013-2015 : Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University (서울대학교 종합약학연구소 연구원)
- 2016-2021 : University of Toronto / University Health Network, Canada (토론토대학교병원 연구원)
논문
- 최근 논문(2020년 이후)
- Soo-Yeon Lee, Hyun-jong Eun, Ki-Young Lee “Effector Binding Alters the Plastic Dimer Interface of the KRAS Protein on the Membrane” Advanced Science 2024 (In press).
- Hyun-jong Eun, Soo-Yeon Lee, Ki-Young Lee “DNA binding reveals hidden interdomain allostery of a MazE antitoxin from Mycobacterium tuberculosis” Biochem Biophys Res Commun. 2024 May 28:710:149898.
- Soo-Yeon Lee, Ki-Young Lee “Conditional Cooperativity in RAS Assembly Pathways on Nanodiscs and Altered GTPase Cycling” Angew Chem Int Ed Engl. 2024 Mar 22;63(13):e202316942.
- Ki-Young Lee “Membrane-Driven Dimerization of the Peripheral Membrane Protein KRAS: Implications for Downstream Signaling” International Journal of Molecular Sciences 2024 Feb 21;25(5):2530.
- Takashi Saitoh, Ha-Neul Kim, Riku Narita, Ibuki Ohtsuka, Weiyu Mo, Ki-Young Lee, Masahiro Enomoto, Geneviève M C Gasmi-Seabrook, Christopher B Marshall, Mitsuhiko Ikura, “Biochemical and biophysical characterization of the RAS family small GTPase protein DiRAS3” Protein Expr Purif. 2023 Dec:212:106361.
- Ki-Young Lee, Mitsuhiko Ikura, Christopher B Marshall, “The Self-Association of the KRAS4b Protein is Altered by Lipid-Bilayer Composition and Electrostatics” Angew Chem Int Ed Engl. 2023 Apr 24;62(18)
- Ki-Young Lee and Bong-Jin Lee “Dynamics-Based Regulatory Switches of Type II Antitoxins: Insights into New Antimicrobial Discovery” Antibiotics 2023 Mar 23;12(4):637
- Ki-Young Lee, Masahiro Enomoto, Teklab Gebregiworgis, Geneviève MC Gasmi-Seabrook, Mitsuhiko Ikura, Christopher B Marshall “Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization” Chemical Science 2021 Sep 7;12(38):12827-12837.
- Christopher B Marshall, Fenneke KleinJan, Teklab Gebregiworgis, Ki-Young Lee, Zhenhao Fang, Ben J Eves, Ningdi F Liu, Geneviève M C Gasmi-Seabrook, Masahiro Enomoto, Mitsuhiko Ikura “NMR in integrated biophysical drug discovery for RAS: past, present, and future” J Biomol NMR. 2020 Nov;74(10-11):531-554.
- Kyu-Yeon Lee, Dong-Gyun Kim, Ki-Young Lee, Chinar Pathak, Ji Sung Koo, Hee-Chul Ahn, Bong-Jin Lee “Structural and functional study of SaAcP, an acylphosphatase from Staphylococcus aureus” Biochem Biophys Res Commun. 2020 Nov 5;532(2):173-178.
- Ki-Young Lee, Zhenhao Fang, Masahiro Enomoto, Genevieve Gasmi-Seabrook, Le Zheng, Shohei Koide, Mitsuhiko Ikura, Christopher B. Marshall “Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement” Angew Chem Int Ed Engl. 2020 Jun 26;59(27):11037-11045.
- Hyun-Jong Eun, Ki-Young Lee, Dong-Gyun Kim, Daseul Im, Bong-Jin Lee “Crystal structure of the YoeB Sa1-YefM Sa1 complex from Staphylococcus aureus” Biochem Biophys Res Commun. 2020 Jun 18;527(1):264-269.
- Zhenhao Fang, Ki-Young Lee, Ku-Geng Huo, Geneviève Gasmi-Seabrook, Le Zheng, Nadeem Moghal, Ming-Sound Tsao, Mitsuhiko Ikura, Christopher B Marshall “Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane” Proc Natl Acad Sci. 2020 Jun 2;117(22):12101-12108.
- Benjamin M M Grant, Masahiro Enomoto, Sung-In Back, Ki-Young Lee, Teklab Gebregiworgis, Noboru Ishiyama, Mitsuhiko Ikura, Christopher B Marshall “Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety” Sci Signal. 2020 Mar 31;13(625):eaaz0344.
- DongWon Park, Hye-Jin Yoon, Ki-Young Lee, Sung-Jean Park, Seung-Ho Cheon, Hyung Ho Lee, Sang Jae Lee, Bong-Jin Lee “Crystal structure of proteolyzed VapBC and DNA-bound VapBC from Salmonella enterica Typhimurium LT2 and VapC as a putative Ca 2+ -dependent ribonuclease” FASEB J. 2020 Feb;34(2):3051-3068.